The emergency triggered by Covid-19 revealed that both the industrial processes and the manufacturing sector must include the pandemic impact, among the unforeseen threats and external environmental stressors. As a direct consequence, the levels of management, technology and internal policy must develop resilience and the impact of adaptation. This challenge was acknowledged by the project “Resmod- Resilience enhancement model”, funded by the European partnership SAF€RA and involving the international Research Teams of The Department of Civil Chemical and Environmental Engineering of the University of Genoa (Italy), the Department of Engineering of the University of Messina (Italy),the Faculty of Safety Engineering of the VSB-Technical University of Ostrava (Czech Republic), and the Faculty of Mechanical Engineering of the University of Belgrade (Republic of Serbia). The present research focuses on developing a conceptual model for the organizational resilience evaluation for different industrial sectors covering both the manufacturing and the process sides and relying on the actual experience gained during the first and second waves of the pandemic emergency. The applied inter-disciplinary research aims at developing an innovative approach for managing emerging pandemic risks, suitable to create new momentum and choices that make adaptation easier. In this regard, as an overall safety umbrella, the organizational resilience assessment and setting-up resilience indicators can support business continuity and help dealing with unexpected events, absorbing the disruptive potential.